Humanity faces a growing array of global risks, which interact and proliferate in ways that are incredibly impactful yet difficult to predict. This trend is increasingly termed ‘polycrisis.’ Businesses will need to be more agile and resilient in order to weather these challenges, and develop stronger forecasting to stay ahead of this rapidly changing landscape. In this panel, we will discuss the particular polycrisis challenges facing the Americas, and how business can proactively protect against them.