A new industrial revolution is unfolding, powered by emerging technologies and digital transitions, impacting most sectors of society across the transatlantic landscape. In order for the European bloc and its key allies, chief among them the United States, to remain both competitive and strategically autonomous, governments and private industry alike must strengthen collaboration to leverage resources for collective interests and long-term capacity building. Which sectors will be most strategic to reduce our dependence on fossil fuels, rare ores, and minerals? What cross-sector partnerships will be essential for navigating the complexities of digitalization while safeguarding the interests of the US and Europe? What steps remain in innovation in technological infrastructure? What is the role of the US-EU relationship in digitalization and its capacities for economic growth?